Sox10 salivary gland. See also Salivary gland.

Sox10 salivary gland. Sox10 labels both benign melanocytes (nevus cells) and the vast majority of melanomas. The immunohistochemical and molecular analyses of MGA revealed that this tumor was a salivary gland-type tumor with a mucinous bronchial gland phenotype. Aug 1, 2016 · www CA (nih. Abstract SOX10 immunoexpression is increasingly recognized in salivary gland tumors, including but not limited to those with myoepithelial, serous acinar, and intercalated duct differentiation. 1 for mucus gland clusters. 14–16 (a) Expression patterns of SOX10 and p63 in the normal human salivary gland with immunohistochemistry. Methods May 3, 2019 · The SRY-related HMG-box 10 (SOX10) protein is a transcription factor known to be crucial in the specification of the neural crest and maintenance of Schwann cells and melanocytes. Jul 1, 2020 · Oncocytomas (OC) in salivary glands are rare benign tumors composed of mitochondria-rich epithelial cells (oncocytes), mostly localized in the parotid gland. It has also been shown to be expressed in nor-mal constituents of salivary glands such as myoepithelial cells, acinar cells, and intercalated ducts [6, 8]. Aug 23, 2024 · Using in situ hybridization for Sox10, we identified two tissue compartments under lingual epithelium that contain Sox10+ cells, i. In this study Role of Sox10 immunostain in diagnostic histopathology Sox10 expression can be seen in a variety of neoplasms including cutaneous adnexal neoplasms, salivary gland neoplasms, breast neoplasms, melanocytic lesions, and peripheral nerve sheath tumours. This finding mimics the pattern of expression in minor salivary glands and may explain the occurrence of weak NKX3. (DOI: 10. SOX10, or SRY-related HMG-box 10 (SOX10), is a tran-scription factor associated with neural crest cells and their resultant mature cells such as melanocytes and Schwann cells [6, 7]. Jun 17, 2016 · SOX10-positive salivary gland tumors: a growing list, including mammary analogue secretory carcinoma of the salivary gland, sialoblastoma, low-grade salivary duct carcinoma, basal cell adenoma/adenocarcinoma, and a subgroup of mucoepidermoid carcinoma. Antibody staining with HPA068898 and CAB003171 in immunohistochemistry. In tumor tissues, S0X10 labels melanoma and tumors of neural crest origin. a Nuclear and cytoplasmic staining in myoepithelial cells in PA whereas luminal cells were largely negative, b S100 expression in Ca ex-PA with diffuse SOX10 Is a Sensitive Marker for Breast and Salivary Gland Adenoid Cystic Carcinoma: Immunohistochemical Characterization of Adenoid Cystic Carcinomas. Immunohistochemistry is a useful tool for diagnosing salivary gland and head and neck tumors. SRY-related HMG-box 10 (SOX10) protein is a transcription factor known to be crucial in the specification of the neural crest and maintenance of Schwann cells and "SOX10-positive salivary gland tumors: a growing list, including mammary analogue secretory carcinoma of the salivary gland, sialoblastoma, low-grade salivary duct carcinoma, basal cell adenoma/adenocarcinoma, and a subgroup of mucoepidermoid carcinoma". 13 cases of Additionally, SOX10 has been identified in various epithelial neoplasms, including breast, ovarian, salivary gland, nasopharyngeal, and bladder cancers, presenting itself as a potential diagnostic and prognostic marker. Its role in The objective of this study was to find whether SOX10 has the potential to serve as a pathological marker in benign and malignant salivary gland tumors and to study its expression in murine development and human major salivary gland tissues. Apr 2, 2025 · Microsecretory adenocarcinoma (MSA) is a newly identified entity in the WHO classification of salivary gland tumors characterized by MEF2C::SS18 fusion. It is also detected in melanocytes and epithelial cells of salivary gland and mammary gland. Salivary gland neoplasms are rare lesions in the head and neck (H&N) pathology realm. A Many reactive and neoplastic salivary gland lesions exhibit oncocytic cells with large, granular eosinophilic cytoplasm rich in mitochondria. With the discovery of new gene fusions specifying distinct salivary gland tumors and restricting the diagnosis of adenocarcinoma NOS, five cases of MSA were We then assessed 173 salivary gland tumors and 108 odontogenic tumors by immunohistochemistry for FOXP1 and SOX10 expression and found that 34/35 (97%) cases of ameloblastomas were diffusely positive for FOXP1 but completely negative for SOX10. They range from indolent to aggressive and can cause significant morbidity and mortality. These tumors have undergone taxonomic drift, with many terms used to describe these tumors over the years (Table 1). 21 Expression of SOX10 as a diagnostic marker has been previously established in salivary gland AdCC and basal-like breast carcinoma 21, 22; however, SOX-10 has not been studied in primary breast AdCC. CK5/6 +ve - luminal squamous balls. Oct 1, 2015 · Read the article Expression of SOX10 in Salivary Gland Oncocytic Neoplasms: A Review and a Comparative Analysis with Other Immunohistochemical Markers on R Discovery, your go-to avenue for effective literature search. 1 distribution compared with SOX10 in the human salivary gland, we collected a normal minor salivary gland tissue block. Nov 1, 2021 · Undifferentiated carcinomas arising at salivary gland and head and neck mucosal sites may originate either de novo or through a process of dedifferentiation of a differentiated carcinoma. Sialoblastoma. SRY related HMG box 10 (SOX10) protein Transcription factor known to be crucial in the specification of the neural crest and maintenance of Schwann cells and melanocytes Expressed in nuclei of melanocytes, peripheral nerves, breast myoepithelial cells, luminal cells of sweat and salivary glands (Am J Surg Pathol 2015;39:826) Nov 14, 2018 · In normal salivary gland tissues SOX10 was expressed in cells of acinus and intercalated ducts. In most of them (n = 8, 80%) the diagnosis was established after excisional biopsy. Oct 5, 2021 · In the salivary gland, GATA3 stains secretory carcinoma, salivary duct carcinoma and other types of salivary gland neoplasms (Head Neck Pathol 2013;7:311). generate human induced pluripotent stem cell-derived salivary gland organoids that serve as a model for salivary gland development and SARS-CoV-2 infection. Several Mar 1, 2021 · Several studies have been conducted to identify salivary gland-specific networks using a mouse submandibular gland model. qPCR was performed to analyze changes in Kit, Sox10, Fgfr2b, and Aqp5 genes, all of which are predicted to be positively regulated by Sox10. p16 +ve - luminal squamous balls. —. Salivary glands are formed by branching morphogenesis with epithelial progenitors forming a network of ducts and acini (secretory cells). These oncocytoid changes can predominate in various benign and malignant salivary tumors, such as oncocytoma/nodular oncytosis, Warthin tumor, secretory carcinoma Jun 17, 2017 · In addition to the salivary gland, other exocrine organs, such as the nasal glands, trachea glands, mammary glands, and pancreas, have tissue-specific acinar cells depending on their functions SOX10-positive salivary gland tumors: a growing list, including mammary analogue secretory carcinoma of the salivary gland, sialoblastoma, low-grade salivary duct carcinoma, basal cell adenoma/adenocarcinoma, and a subgroup of mucoepidermoid carcinoma. We seek to detail its histopathological and immunohistochemical features, clarify differential diagnoses, and evaluate clinical outcomes. Most of salivary gland neoplasms (benign and malignant) are characterized by recurrent gene fusions. , intercalated ductal (adenoid cystic carcinoma. Mucoepidermoid carcinoma. —To review immunohistochemical markers, which can aid in the diagnosis of selected salivary gland and head and neck tumors. Background Intraductal carcinoma (IDC) of the salivary glands is a confounding entity, our understanding of which continues to evolve. Expression of SOX10 in salivary gland oncocytic neoplasms: a review and a comparative analysis with other immunohistochemical markers. The aim of this study was to evaluate the diagnost … Mar 1, 2025 · In this study, we investigated potential markers for HCCC based on the characteristics of minor salivary gland acini, from which these tumors may originate. They may be encountered in a wide age range, including frequent paediatric cases. While in the latter group the diagnosis is largely dependent on the identification of the differentiated component or recognition of a specific genotype, the classification of undifferentiated carcinomas that Microsecretory adenocarcinoma (MSA) is a recently described salivary gland tumor with a characteristic histologic and immunophenotypic profile and recurrent MEF2C-SS18 fusions. However, despite these associations, further research is imperative to elucidate its precise role in these malignancies. With the discovery Aug 19, 2025 · Title: SOX10-Internal Tandem Duplications and PLAG1 or HMGA2 Fusions Segregate Eccrine-Type and Apocrine-Type Cutaneous Mixed Tumors. Historically, MEC is defined as a “triphasic” tumor comprising mucous, epidermoid (squamoid) and intermediate cells [1]. In benign tumors, SOX10 expression was observed in all pleomorphic adenoma (48/48), and basal cell We evaluated SOX10 (SRY-related HMG-box 10) in differentiating acinic cell carcinoma (AciCC) from other salivary gland neoplasms with oncocytic features on fine-needle aspiration cell blocks (FNA CB) and compared its performance to DOG1 (discovered on gastrointestinal stromal tumor 1). Jul 7, 2013 · Keywords: SOX10, salivary adenoid cystic carcinoma, basal-like breast carcinoma, melanoma, neural stem markers Adenoid cystic carcinoma (ACC) of the salivary gland, the second most frequent salivary cancer, is notorious for nerve invasion and late recurrence (Papaspyrou et al, 2011). The diagnosis of salivary gland carcinomas (SGC) rests mainly on histology, but immunohistochemical and molecular investigations are often necessary fo … For non-breast carcinoma, a high SOX10/GATA3 expression rate was found in melanoma (77. Apr 5, 2013 · In normal human salivary gland tissue, SOX10 expression was specific to the nuclei of acini and both luminal and abluminal cells of intercalated ducts but not in other sites. Hum Pathol56: 134–42. Methods: We reviewed the current literature involving the Sep 13, 2021 · Myoepithelial carcinoma of the salivary gland is a carcinoma that is composed exclusively or near exclusively of myoepithelial cells It may arise de novo or ex Jul 9, 2024 · To determine NKX3. This labeling allowed for visualization and efficient isolation of primary tissues in young adult mice (8-10 weeks). On small biopsy, the most important information to be conveyed for clinical management is the distinction between a benign/low grade tumor and a high grade carcinoma. These include two new entities – secretory carcinoma and sclerosing polycystic Jul 9, 2024 · Microsecretory adenocarcinoma (MSA) is a new type of salivary gland neoplasm identified in the 2022 World Health Organization Classification of Head and Neck Tumour (Skalova et al. SOX10 is useful in the differential diagnosis between myoepithelial carcinoma with clear cell features and hyalinizing clear cell carcinoma. Tumours that start from these tissues also make SOX10. Follow-up showed no evidence of disease in 23 cases across all 3 tumor types. In carcinomas, SOX10 expression has been reported in adenoid cystic carcinoma of salivary gland, some squamous cell carcinoma of head and neck and a small subset of lung adenocarcinoma. The treatment of choice is simple excision. Therefore, Sox10 controls plasticity and multi-potency of epithelial KIT + cells in secretory organs, such as mammary, lacrimal, and salivary glands. Mar 15, 2025 · Mucoepidermoid carcinoma (MEC) represents the most common salivary gland (SG) malignancy accounting for 2. Role of ancillary techniques in the differential diagnosis of salivary gland carcinomas. A significant proportion of SG carcinomas develop metastases, with increased diagnostic difficulty at metastatic sites. Papillary salivary gland neoplasms are rare tumors usually arising in the minor salivary glands of the oral cavity. Transcriptional repressor GATA binding 1 (TRPS1), a novel immunohistochemical marker for breast cancer, has been found to stain certain SGNs. Histologically, OCs are well circumscribed nodules composed of mitochondria-rich cells arranged in nests, sheets, or microcystic or macrocystic growth patterns [1]. Herein, two cases of carcinoma arising in pleomorphic adenoma of the parotid gland and showing diffuse expression of myoepithelial Download Table | Immunohistochemical profile of salivary gland tumors from publication: SOX10 is a novel marker of acinus and intercalated duct differentiation in salivary gland tumors: A clue to Abstract SOX10 is a transcription factor that is essential for the generation of neural crest cells, their survival, and maintenance of pluripotency. This was then incubated with Aug 7, 2024 · Molecular, immunohistochemical, and clinical understanding of salivary gland lesions has advanced in recent years, yielding reclassification and a shift in nomenclature of benign and malignant neopla Summary of SOX10 (DOM, SOX-10, WS2E, WS4) expression in human tissue. Low-grade salivary duct carcinoma. The addition of S100+, SOX10+ and MUC4+, in addition to mammaglobin+ weighs against cystadenoma and with the correct morphology, supports macrocystic secretory carcinoma. IHC Features: [1] S-100 +ve - diffuse and strong. , 2020) -- minor salivary glands connected to the trench of circumvallate and foliate papillae (Hand et al. We evaluated the efficacy and limitations of preoperative diagnosis with CNB specimens collected using a newly developed 20 Nov 5, 2024 · We also used a Sox10-Cre::tdTomato (hereafter referred to as RFP) reporter mouse line, which labeled von Ebner's glands, a type of minor salivary gland connected to the trough of circumvallate and foliate taste papillae. Because only six cases of MSA have been published, its complete Salivary gland ductal ectasia, along with the overlying papillary hyperplasia, may mimic the biphasic tumorous growth pattern of SialP, making discrimination extremely difficult. 34 In addition, Miettinen et al have shown consistent SOX10 expression in multiple malignant salivary gland neoplasms, including acinic cell carcinoma, adenoid cystic Feb 12, 2019 · However, overexpression of Sox10 in these ductal progenitors enhances their plasticity toward KIT + progenitors and induces differentiation into secretory units. Background Recent findings in molecular pathology suggest that genetic translocation and/or overexpression of oncoproteins is important in salivary gland tumorigenesis and diagnosis. A total of 12 cases of breast AdCCs were studied; 17 age-matched salivary gland AdCCs and 5 metastatic AdCCs (1 breast and 4 salivary gland primaries) were also examined. However, it is now agreed that CanAd are a Mar 30, 2012 · The aim of this study is to characterize DOG1 expression patterns in normal human salivary tissues and a broad variety of salivary gland tumors. The most common benign salivary gland neoplasm is pleomorphic adenoma. , 2020). SOX10‐positive salivary gland tumors: a growing list, including mammary analogue secretory carcinoma of the salivary gland, sialoblastoma, low‐grade salivary duct carcinoma, basal cell adenoma/adenocarcinoma, and a subgroup of mucoepidermoid carcinoma. Methods: We reported a cocktail factor approach to promote the Benign neoplasms are more common in major salivary glands whereas malignant neoplasms represent greater proportion of the tumors in the minor salivary glands. Salivary gland tumors are relatively rare and morphologically diverse and heterogeneous tumors; therefore, histogenesis-based tumor markers are sorely needed to aid in diagnosing and determining the cell type of origin. Salivary gland pleomorphic adenoma (SGPA), the most common salivary gland tumor, has a notoriously high probability of developing into carcinoma ex-pleomorphic adenoma (CEPA), the fifth most common salivary gland carcinoma. Objectives: We evaluated SOX10 (SRY-related HMG-box 10) in differentiating acinic cell carcinoma (AciCC) from other salivary gland neoplasms with oncocytic features on fine-needle aspiration cell blocks (FNA CB) and compared its performance to DOG1 (discovered on gastrointestinal stromal tumor 1). Jun 20, 2024 · DOG1 and SOX10 are expressed in benign acinar cells and intercalated duct cells and other salivary gland neoplasms; however, strong diffuse expression of these markers can help distinguish acinic cell carcinoma from other salivary gland neoplasms. Oct 1, 2015 · SOX10 is a transcription factor expressed from the developmental stage to adulthood in acinar and intercalated ducts of major salivary glands, and in some salivary gland tumors. Aug 2, 2024 · If have symmetric enlargement of salivary glands with no discrete mass, consider sialadenosis, a benign condition associated with systemic disorders like diabetes, malnutrition, and cirrhosis. In normal salivary gland tissues SOX10 was expressed in cells of acinus and intercalated ducts. humpath. Category:. 2016. Article Screening and Eligibility Evaluation Titles and abstracts of all articles published in english language were screened by 2 independent authors (G. The aim of this study was to investigate SOX10 expression more thoroughly in the salivary gland neoplasms, including mammary analogue secretory carcinoma and hyalinizing clear cell carcinoma harboring specific genetic rearrangements. Feb 12, 2019 · The KIT/FGFR2b-Sox10 axis marks the earliest multi-potent and tissue-specific progenitors of exocrine glands. e. Additionally, SOX10 has been identified in various epithelial neoplasms, including breast, ovarian, salivary gland, nasopharyngeal, and bladder cancers, presenting itself as a potential diagnostic and prognostic marker. The submandibular glands (SMGs) of mice manifest as a thickening of the oral epithelium at embryonic day 11. In this study, we identified four p16 or HPV-positive SCC cases and one p16-negative case (NC) that demonstrated SOX-10 positivity. Methods: A total of 113 cases of surgically resected salivary gland neoplasms at the NationalCancer Center from January 2007 to March 2017 were identified. Using Oct 17, 2022 · Tanaka et al. Jan 1, 2015 · Context. —Immunohistochemistry is a useful tool for diagnosing salivary gland and head and neck tumors. Recent studies indicate that this protein is expressed in tumors of the nervous system, salivary glands, breast, soft tissues and melanoma cells. , Head Neck Pathol 16:40-53, 2022) and is characterized by a unique set of histomorphologic and immunohistochemical features and a recurrent MEF2C::SS18 fusion. All breast (100%) and metastatic Jun 25, 2013 · Main Adenoid cystic carcinoma (ACC) of the salivary gland, the second most frequent salivary cancer, is notorious for nerve invasion and late recurrence (Papaspyrou et al, 2011). MSA was initially misdiagnosed as another salivary Expression of SOX10 in Salivary Gland Oncocytic Neoplasms: A Review and a Comparative Analysis with Other Immunohistochemical Markers. Literature review and authors' personal practice experience. May 31, 2023 · ACMT, HCR-ACMT, and salivary gland pleomorphic adenoma clustered together, whereas myoepithelioma with fusions of EWSR1, FUS, PBX1, PBX3, POU5F1, and KLF17 formed another cluster. Microsecretory adenocarcinoma (MSA) is a newly identified entity in the WHO classification of salivary gland tumors characterized by MEF2C::SS18 fusion. May 3, 2019 · The SRY-related HMG-box 10 (SOX10) protein is a transcription factor known to be crucial in the specification of the neural crest and maintenance of Schwann cells and melanocytes. S. SOX10 (SRY-related HMG-box gene 10) is expressed specifically in neural crest cells during early embryonic stages [17]. GFAP +ve - luminal. 2016 Oct;56:134-42. Salivary gland (SG) neoplasms (SGNs) display considerable immunophenotypic diversity. The tumor represents about 1% of malignant salivary gland neoplasms, while only about 0. Oct 12, 2018 · Weinvestigated PLAG1, SOX10, and Myb protein expression in various salivary gland neoplasm tissues. Jan 5, 2021 · Sialadenoma papilliferum (SP) is a rare, benign salivary gland neoplasm sharing similar histopathologic features and harboring the same genetic alterations, BRAF V600E or HRAS mutations, with syringocystadenoma papilliferum. After heat-induced epitope retrieval, the sections were incubated with primary antibody against NKX3. However, its specificity and distribution is not well established. Oct 1, 2023 · Genome Doubling Shapes High-Grade Transformation and Novel EWSR1::LARP4 Fusion Shows SOX10 Immunostaining in Hyalinizing Clear Cell Carcinoma of Salivary Gland Kenya Kobayashi a b , Masahito Kawazu c d , Seiichi Yoshimoto b , Toshihide Ueno d , Go Omura b , Yuki Saito a , Mizuo Ando e , Eigitsu Ryo f , Airi Sakyo g , Akihiko Yoshida f g Mar 22, 2024 · Salivary gland carcinosarcoma is a high grade, aggressive salivary gland malignancy characterized by a variable combination of malignant epithelial and sarcomatous tumor components Apr 1, 2020 · Salivary gland tumours are one of the most difficult areas of diagnostic pathology, with significant morphological diversity and many overlapping features. , Rema A. Positive Metastatic malignant melanoma 119 +ve of 125 cases. In this study, we analyzed 40 cases intending to elucidate their features further. In benign tumors, SOX10 expression was observed in all pleomorphic adenoma (48/48), and basal cell adenoma (3/3), but not in other benign tumors. Basal cell adenoma / basal cell adenocarcinoma. SOX10 is involved in the generation of myelin through interaction with OLIG1. The treatment of choice is simple Jul 30, 2021 · Pleomorphic adenoma is a benign triphasic salivary gland neoplasm composed of epithelial (ductal) cells, myoepithelial cells and chondromyxoid stroma Moved PermanentlyThe document has moved here. Microscopically, SP shows an Major advances in our understanding of salivary gland (SG) progenitors are due to murine genetic lineage tracing, which has revealed lineage relationships during gland development and within postnatal glands. Pleomorphic adenoma (PA), the most frequent salivary gland tumor, is driven by chromosomal May 1, 2018 · Salivary gland neoplasms are rare, yet histologically diverse, posing a diagnostic challenge to many practicing pathologists. Interestingly, this complication reflects the structural similarity between the salivary glands and breast, both of which play an exocrine role. Louis Souzan Sanati Washington University School of Medicine in St. 21 Expression of SOX10 as a diagnostic marker has been previously established in salivary gland AdCC, basal-like breast carcinoma, and benign breast myoepithelial Mar 19, 2024 · Salivary gland tumors can display a spectrum of oncocytoid features, characterized by cells showing enlarged nuclei, prominent nucleoli, and abundant eosinophilic granular cytoplasm due to the accumulation of altered mitochondria. Dec 15, 2023 · Additionally, SOX10 has been identified in various epithelial neoplasms, including breast, ovarian, salivary gland, nasopharyngeal, and bladder cancers, presenting itself as a potential diagnostic and prognostic marker. 9%, predominately expressed SOX10), urothelial carcinoma (82. Because only six cases of MSA have been published, its complete clinicopathologic spectrum is unclear, and its biologic behavior has not been documented. Surgical resection remains the mai Nov 14, 2022 · Sox10 also marks normal myoepithelial cells of salivary gland and bronchial and mammary ducts and lobules, and it stains the myoepithelial component of salivary gland neoplasms such as myoepithelioma or pleomorphic adenoma. At least four forms have been elucidated based on histomorphology, immunophenotype, and molecular profile: (1) intercalated duct-like, S100/SOX10+ with frequent NCOA4:: RET fusions; (2) oncocytic, S100/SOX10+ with TRIM33:: RET, NCOA4:: RET, and BRAF V600E; (3 SOX10, or SRY-related HMG-box 10 (SOX10), is a transcription factor associated with neural crest cells and their resultant mature cells such as melanocytes and Schwann cells [6, 7]. Mar 1, 2025 · The predominant clinical differential diagnosis included salivary gland tumors (SGT), such as polymorphic adenocarcinoma, PA, and CAD, in addition to mucocele and nasolabial cyst. PMID 27327192. Pankeratin +ve - diffuse and strong. In tumor tissues, SOX10 labels melanoma and the tumor of neural crest origin. 2015;59 (5):384–390. Basaloid squamous cell carcinoma (SCC) is a unique variant of SCC that shows morphologic Keratocystoma Keratocystoma is a rare salivary gland neoplasm, which occurs exclusively in the parotid gland. In this article we thoroughly evaluated SOX10 expression in salivary gland tumors. Basaloid squamous cell carcinoma (SCC) is a unique variant of SCC that shows Feb 12, 2019 · However, overexpression of Sox10 in these ductal progenitors enhances their plasticity toward KIT + progenitors and induces differentiation into secretory units. Data Sources. SRY-related HMG-box 10 (SOX10) protein is a transcription factor known to be crucial in the specification of the neural crest and maintenance of Schwann cells and SOX10-positive salivary gland tumors: a growing list, including mammary analogue secretory carcinoma of the salivary gland, sialoblastoma, low-grade salivary duct carcinoma, basal cell adenoma/adenocarcinoma, and a subgroup of mucoepidermoid carcinoma. Core needle biopsy (CNB) allows the collection of a small, intact specimens from the tumor center for detailed analysis. Pleomorphic adenoma is the most recurrent form of Context. Apr 8, 2021 · Basal cell adenoma is a benign salivary tumor composed of nests and cords of small basaloid cells with inner ductal epithelial cells Jan 18, 2024 · Hsieh M-S, Lee Y-H, Chang Y-L. Salivary gland tumors & processes Acinic cell carcinoma Authors: Arash H. Hum Pathol. Submandibular, lacrimal, and minor salivary glands of the palate, tonsil, larynx, and sinonasal tract can also be affected [1,4]. p63 -ve. Background: Recent findings in molecular pathology suggest that genetic translocation and/or overexpression of oncoproteins is important in salivary gland tumorigenesis and diagnosis. References In normal human salivary gland tissue, SOX10 expression was specific to the nuclei of acini and both luminal and abluminal cells of intercalated ducts but not in other sites. 1 staining was observed in only 1 HCCC case. Jan 1, 2022 · Abstract Diagnosis of salivary gland neoplasms can be challenging for surgical pathologists due to low incidence of tumors as well as overlapping histologic features. Rao, M. In salivary glands, SOX10 is also expressed by acinar cells and in the intercalated ducts (including both luminal and abluminal cells). Most salivary gland tumors exhibit polymorphic growth pattern and some may have dual cell composition. 6 – 13 Subsequently it has been recognized that Sox10 is also expressed in myoepithelial or basal cells, especially in the breast and salivary glands and in some tumors of these sites. SOX10 is a sensitive marker for breast and salivary gland adenoid cystic carcinoma: Immunohistochemical characterization of adenoid cystic carcinomas Chen Yang Washington University School of Medicine in St. Submandibular, lacrimal, and minor salivary glands of the palate, tonsil, larynx, and sinonasal tract can also be affected [1, 4]. 1 staining and SOX10-positive cases in HCCC. Feb 16, 2021 · Introduction Multi-lineage differentiation can be observed in salivary glands carcinomas, especially in myoepithelial cell carcinoma [1]. Salivary gland and head and neck tumors include a large diverse group of Abstract Objectives: We evaluated SOX10 (SRY-related HMG-box 10) in differentiating acinic cell carcinoma (AciCC) from other salivary gland neoplasms with oncocytic features on fine-needle aspiration cell blocks (FNA CB) and compared its performance to DOG1 (discovered on gastrointestinal stromal tumor 1). Oct 9, 2021 · SOX10 is a common immunostain. It has also been shown to be expressed in normal constituents of salivary glands such as myoepithelial cells, acinar cells, and intercalated ducts [6, 8]. At least four forms have been elucidated based on histomorphology, immunophenotype, and molecular profile: (1) intercalated duct-like, S100/SOX10+ with frequent NCOA4::RET fusions; (2) oncocytic, S100/SOX10+ with TRIM33::RET, NCOA4::RET, and BRAF V600E; (3 Aug 7, 2024 · Molecular, immunohistochemical, and clinical understanding of salivary gland lesions has advanced in recent years, yielding reclassification and a shift in nomenclature of benign and malignant neopla Abstract SOX10 immunoexpression is increasingly recognized in salivary gland tumors, including but not limited to those with myoepithelial, serous acinar, and intercalated duct diferentiation. Tissue Salivary gland tumors are a rare tumor entity within malignant tumors of all tissues. SOX10 is a protein that is made by cells in the skin, salivary glands, and nerves. Objective. Nuclei negative, cytoplasm positive. Some of these tumors are also common in salivary glands, so that their sites of origin in the bronchus have been supposed to be the bronchial submucosal glands [7]. Oct 1, 2016 · Transcription factor SRY-related HMG-box 10 (SOX10) is an important marker for melanocytic, schwannian, myoepithelial, and some salivary gland tumors. We investigated PLAG1, SOX10, and Myb protein expression in various salivary gland neoplasm tissues. At the best of our knowledge, only rare cases of salivary glands tumors with abundant melanin pigment and/or expression of multiple melanocytic markers (S-100, SOX10, HMB45, MART-1 and MITF) have been reported in the literature [2 – 11]. Adopting a systematic diagnostic approach with a focus on patterns of Aug 1, 2020 · Thus IHC detection of SOX10 has been used to detect nerve sheath tumors and melanoma. D. These results suggest that regenerative therapy targeting Sox9+ cells is a promising approach to treat radiation-induced salivary gland injury. Jun 27, 2024 · Background: Intraductal carcinoma (IDC) of the salivary glands is a confounding entity, our understanding of which continues to evolve. Feb 17, 2024 · SOX10-positive salivary gland tumors: a growing list, including mammary analogue secretory carcinoma of the salivary gland, sialoblastoma, low-grade salivary duct carcinoma, basal cell adenoma/adenocarcinoma, and a subgroup of mucoepidermoid carcinoma. In this article we thoroughly evaluated SOX10 expression in salivary gland tumors. SOX10 is a transcription factor that plays an important role in the formation, specication and dierentiation of neural crest cells. Jul 14, 2025 · Purpose This study aims to characterize the rare morphological variant of nasopharyngeal carcinoma known as reticular and myxoid nasopharyngeal carcinoma (RMNK-NPC), which poses diagnostic challenges due to its resemblance to salivary gland tumors. In this study Jan 12, 2019 · SOX10 immunoexpression is increasingly recognized in salivary gland tumors, including but not limited to those with myoepithelial, serous acinar, and intercalated duct differentiation. May 27, 2024 · Context. In normal tissues, SOX10 is expressed in Schwann cells and glial cells in the nervous system. Keywords: Adenoid cystic carcinoma; GATA3; Polymorphous adenocarcinoma; SOX10; Salivary gland. [17, 18] Normal major salivary glands are transcription factors that are usually expressed in acinar and intercalar duct SOX10 positivity is primarily helpful in Oncocytomas (OCs) in salivary glands are rare benign tumors composed of mitochondria-rich epithelial cells (oncocytes), mostly localized in the parotid gland. Jan 26, 2023 · Mucous gland adenoma (MGA) is a rare benign tumor that usually arises in the proximal airway and consists of mucus-secreting cells resembling bronchial glands. Jul 23, 2023 · Hyalinizing clear cell carcinoma (HCCC) is a rare indolent malignant tumor of minor salivary gland origin with EWSR1::ATF1 rearrangement. During this process, epithelial progenitors specialise into distal (tips of the gland) and proximal (the stalk region) Jun 1, 2023 · Here, we report 2 cases of bronchial/tracheal MGA. Nuclear expression mainly in glial cells and salivary gland. Sustained SOX10 expression in later embryonic stages and in postnatal mice is evident in neural crest lineage cell types such as glial cells [18, 19], melanocytes [20], and salivary gland cells [21]. SP most commonly occurs in the hard palate and in older adults. Aug 14, 2023 · The search strategy was as following: [Salivary gland tumors of head and neck AND S-100/MMG/SOX10/DOG 1 IHC]. Mar 11, 2024 · Background: The derivation of salivary gland (SG) progenitors from pluripotent stem cells (PSCs) presents significant potential for developmental biology and regenerative medicine. Recent studies have shown that, among tumors, SOX10 is commonly expressed in melanomas, including desmoplastic melanomas, tumors with Schwann cell differentiation, and some salivary gland neoplasms, particularly those with myoepithelial Jan 31, 2018 · This is similar to the results of a recently published study by Nelson et al, who noted frequent SOX10 expression (71%) in patients with ER negative metastatic breast carcinoma. [1] Head and neck pathology Salivary gland tumours: [2] Secretory carcinoma of the salivary gland. Conclusions. Primary salivary gland tumors may also express SOX10 and/or GATA3 (21 - 24) complicating matters even more. Their classification has been historically confusing due to overlapping Jun 6, 2017 · Salivary glands are formed by branching morphogenesis with epithelial progenitors forming a network of ducts and acini (secretory cells). In benign tumors, SOX10 expres- sion was observed in all pleomorphic adenoma (48/48), and basal cell adenoma (3/3), but not in other benign All other benign and malignant salivary gland neoplasms were PLAG1-negative. ) and the articles that did not meet the eligibility criteria were Nov 1, 2024 · Abstract Salivary gland-like tumors of the breast are rare neoplasms that share morphologic, immunophenotypic, and/or genetic features with their salivary gland counterparts, highlighting a shared underlying histopathogenesis in most cases. Originally thought to be derived from terminal duct origin [1, 2], there has been controversy about origin and separation from other salivary gland neoplasms. Acta Cytol. 8–16% of all SG neoplasms and 12–30% of SG carcinomas, respectively. Jun 1, 2018 · All of these four tumors are described in the WHO classification [6]. Aberrant SOX10 and RET expressions in patients with Hirschsprung disease. Data Sources. Material and Methods: An analytical cross-sectional study was designed. 18–20 Until recently, nothing was known about the molecular underpinnings of this rare tumour, but a recent study demonstrated that seven of seven keratocystomas harboured RUNX2 rearrangements when Nov 30, 2015 · Citations (33) References (19) In the context of salivary gland neoplasms, SOX10 expression has been identified in tumors arising from acinar and intercalated ductal cells [57] [58] [59]. Hyalinizing clear cell carcinoma (HCCC) is a rare indolent malignant tumor of minor salivary gland origin with EWSR1::ATF1 rearrangement. Objective. Positive in basal cell adenoma. 1159/000441890. 21 Expression of SOX10 as a diagnostic marker has been previously established in salivary gland AdCC and basal-like breast carcinoma 21, 22; however, SOX-10 has not Therefore, Sox10 controls plasticity and multi-potency of epithelial KIT + cells in secretory organs, such as mammary, lacrimal, and salivary glands. , 1999; Yu et al. Here, we present an updated and expanded experience of 24 MSA May 3, 2019 · SOX10 Is a Sensitive Marker for Breast and Salivary Gland Adenoid Cystic Carcinoma: Immunohistochemical Characterization of Adenoid Cystic Carcinomas. ession of SOX10 in malignant tumors of salivary gland of intercalated d. Based on these findings, Sox10 has been explored as a marker for Schwannian and melanocytic tumors of skin and soft tissue. Louis Lingxin Zhang Washington University School of Medicine in St. References Salivary gland tumors with myoepithelial differentiation: pleomorphic adenoma, myoepithelioma, basal cell adenoma, adenoid cystic carcinoma, polymorphous adenocarcinoma, epithelial-myoepithelial carcinoma, sialoblastoma (Acta Histochem Cytochem 2012;45:269) Mammary analogue secretory carcinoma (Head Neck Pathol 2015;9:85) Others: S100 staining in salivary gland tumours. Feb 15, 2025 · Background: Salivary gland cancers (SGCs) are a rare and heterogeneous group of malignancies, accounting for approximately 5% of head and neck cancers. Epub 2016 Jun 17. However, SOX10 expression has not been extensively evaluated in other epithelial tumors that can mimic salivary origin. Here, authors identify FGF7-FGFR2-MAPK signaling as a regenerative target, critical for myoepithelial-acinar All other benign and malignant salivary gland neoplasms were PLAG1-negative. SRY-related HMG-box 10 (SOX10) protein is a transcription factor known to be crucial in the specification of the neural crest and maintenance of Schwann cells and melanocytes SOX10 (SRY-associated HMG-box10) is known to play an important role in the development of the neural crystal and has a strong expression in Schwannomas and melanocytic tumors. The presence of melanin pigment and melanocytic markers expression have been rarely reported in salivary gland tumors. Nov 29, 2018 · SOX10 immunoexpression is increasingly recognized in salivary gland tumors, including but not limited to those with myoepithelial, serous acinar, and intercalated duct differentiation. 1 (1:200; CellMarque; EP356) and labeled with Alexa Fluor 594-labeled donkey anti-mouse IgG (HþL) (1:250; Molecular Probes). Jan 10, 2015 · SOX10 is a transcription factor expressed from the developmental stage to adulthood in acinar and intercalated ducts of major salivary glands, and in some salivary gland tumors. —Literature review and authors’ personal practice experience. During this process, epithelial progenitors specialise into distal (tips of the gland) and proximal (the stalk Immunohistochemical analysis of SOX10 expression in mouse embryonic (A) and human adult (B) salivary glands. To review immunohistochemical markers, which can aid in the diagnosis of selected salivary gland and head and neck tumors. gov). There are more than 20 malignant and 15 benign salivary gland neoplasms in the 5th edition of the World Health Organization classification of H&N tumors. Pathologically, the tumor cells possess a clear cytoplasm in a background of hyalinized stroma. Aug 1, 2021 · SOX10-positive salivary gland tumors: a growing list, including mammary analogue secretory carcinoma of the salivary gland, sialoblastoma, low-grade salivary duct carcinoma, basal cell adenoma/adenocarcinoma, and a subgroup of mucoepidermoid carcinoma Dec 1, 2019 · SOX10 immunoexpression is increasingly recognized in salivary gland tumors, including but not limited to those with myoepithelial, serous acinar, and intercalated duct differentiation. 1007/S12105-018-0990-7) SOX10 immunoexpression is increasingly recognized in salivary gland tumors, including but not limited to those with myoepithelial, serous acinar, and intercalated duct differentiation. Thus, SOX10 is a novel marker for diagnosing and understanding the histogenesis of salivary gland tumors. Our findings suggest SOX-10 can be positive in non-salivary gland tumors of the HN area and should be used cautiously and in an appropriate context. Basaloid squamous cell carcinoma (SCC) is a unique variant Abstract Salivary gland tumors are relatively rare and morphologically diverse and heterogeneous tumors; therefore, histogenesis-based tumor markers are sorely needed to aid in diagnosing and determining the cell type of origin. Sample size was 90 and categorised into two groups i. Moreover, we also discuss the histologic, immunohistochemical, and genetic distinction between MGA and histologic mimics. Generally, the tumor cells are positive for p63 and p40 and negati … Mar 1, 2025 · In this study, we investigated potential markers for HCCC based on the characteristics of minor salivary gland acini, from which these tumors may originate. Salivary gland tumors are relatively rare and morphologically diverse and heterogeneous tumors; therefore, histogenesis-based tumor markers are sorely needed to aid in diagnosing and determining Aug 21, 2014 · Canalicular adenoma (CanAd) is an uncommon benign salivary gland neoplasm. The current World Health Organization (WHO) 4th edition of head and neck tumors recognizes 31 types of unique salivary gland epithelial neoplasms, including 20 malignant and 11 benign entities. 2% of all tumors, predominantly in the major salivary glands (parotid >>> submandibular gland) [17 – 19], and usually in adults (only rarely reported in pediatric patients) [5, 20]. Newly Aug 29, 2018 · INTRODUCTION Salivary gland cytology is notoriously challenging, with many diagnostic pitfalls secondary to the overall rarity of salivary neoplasms, the diversity of neoplasms (with 42 distinct entities outlined in the current World Health Organization Classification 1), and the frequent morphologic overlap between tumor types. Moreover, the murine model suggested that SOX10 continued to be expressed from the developmental stage to adulthood in the acinar and both luminal and abluminal intercalated ducts in the major salivary gland. 5 and invaginate into the underlying mesenchyme. Clinically, SP is most likely to be diagnosed as a squamous papilloma. Despite their rarity, advances in molecular profiling have revealed a variety of genetic and molecular pathways, many of which are potentially actionable with targeted therapies. SOX10 is a known marker for serous gland clusters and NKX3. 4%). See also Salivary gland. Here, we report 2 cases of MGAs and describe their morphologic, immunohistochemical, and molecular profiles in comparison with 19 pulmonary tumors of 5 other histologic types with mucinous cells (invasive mucinous adenocarcinoma Jun 30, 2022 · Objective: To determine the level of immunohistochemical expression of SOX10 in malignant tumors of salivary gland of intercalated ductal and excretory ductal origin. The monophasic or biphasic tumors exhibited a growth pattern of interconnected anastomosing trabeculae and canaliculi, accompanied by a classical pleomorphic Dec 15, 2023 · Additionally, SOX10 has been identified in various epithelial neoplasms, including breast, ovarian, salivary gland, nasopharyngeal, and bladder cancers, presenting itself as a potential diagnostic and prognostic marker. The most common are malignant mucoepidermoid carcinoma, adenoid cystic carcinoma, and acinic cell carcinoma. A total of 156 formalin-fixed paraffin-embedded May 12, 2021 · Microsecretory adenocarcinoma (MSA) is a recently described salivary gland tumor with a characteristic histologic and immunophenotypic profile and recurrent MEF2C-SS18 fusions. Lahoutiharahdashti, M. In diagnostic histopathology, Sox10 immunostain is a helpful ancillary test due to its high sensitivity for melanocytic and peripheral nerve sheath neoplasms, and its role in distinguishing triple-negative breast carcinomas from gynaecological carcinoma, cutaneous adnexal neoplasms and salivary glands neoplasms from histological mimics. Extensive oncocytic metaplasia of pleomorphic adenoma (PA) and myoepithelioma (ME) can be diagnos … The SRY-related HMG-box 10 (SOX10) protein is a transcription factor known to be crucial in the specification of the neural crest and maintenance of Schwann cells and melanocytes. All breast (100%) and metastatic (100%) AdCCs and all but 2 salivary gland AdCCs showed diffuse nuclear staining (>50% of cells) for SOX10. 021. Jul 25, 2023 · Salivary gland cancers are a rare, histologically diverse group of tumors. To investigate TRPS1 While this is the first series to compare SOX10 and GATA3 staining in these two tumor types, their frequent expression and similar staining patterns render them of limited value in discriminating between these neoplasms. , connective tissue core and von Ebner’s glands (vEGs) (Yu et al. We then assessed 173 salivary gland tumors and 108 odontogenic tumors by immunohistochemistry for FOXP1 and SOX10 expression and found that 34/35 (97%) cases of ameloblastomas were diffusely positive for FOXP1 but completely negative for SOX10. May 3, 2019 · Breast adenoid cystic carcinomas (AdCCs) can pose diagnostic difficulty due to their rarity, particularly on limited biopsy material. Basaloid squamous cell carcinoma (SCC) is a unique variant of SCC that shows With the advancement of molecular testing and the routine use of immunohistochemical stains, salivary gland tumours previously categorized as adenoma or adenocarcinoma, not otherwise specified, are being reclassified with distinct diagnoses. One study demonstrated immunopositivity of SOX10 in luminal/abluminal cells of AdCC, EMC, ACC, Ca-ex-PA, myoepithelioma and MC with consistent absence of expression in squamous cell carcinoma (SCC), MEC and SDC. and M. Adopting a systematic diagnostic approach with a focus on patterns of Sep 1, 2020 · A vast majority of OCs arises in the parotid gland. Aug 9, 2021 · 15 - 30% are malignant Submandibular gland: 10% of all salivary gland tumors 40 - 45% are malignant Minor salivary glands (including sublingual glands and seromucinous glands of the upper aerodigestive tract): 20% of all salivary gland tumors 70 - 90% of sublingual gland tumors and 50% of minor salivary gland tumors are malignant Sep 1, 2020 · A vast majority of OCs arises in the parotid gland. SOX10 showed nuclear staining. SOX10 immunoexpression is increasingly recognized in salivary gland tumors, including but not limited to those with myoepithelial, serous acinar, and intercalated duct differentiation. Given that these tumors are triple-negative breast cancers with favorable prognosis, accurate diagnosis is critical for clinical management. Sox10 expression in basal-type breast carcinoma To better understand the significance of SOX10 expression in cancer in general and in ACC in particular, we explored SOX10 expression in 1764 View of SOX10 EXPRESSION IN SELECTIVE MALIGNANT SALIVARY GLAND TUMORS OF INTERCALATED AND EXCRETORY DUCTAL ORIGIN Oct 14, 2023 · Restoring salivary acinar cells after gland damage is a major clinical challenge. K. Hyalinizing clear cell carcinoma of the salivary gland is a rare tumor, first reported in 1994 [8]. Mar 1, 2022 · Finally, we show that Sox9 + cells are capable of forming organoids in vitro and that transplanting these organoids into salivary glands after radiation partially restored salivary gland functions. The latest WHO classification has attempted to simplify the classification but there are still more than 30 tumours for the pathologist to grapple with. The red arrow in A points to the developing duct, whereas the black arrow shows the acinus. Other carcinomas, including cancers from lungs, showed very low expression for the marker combination. Serous acini, intercalated duct and striated duct of normal parotid glands. ctal and excretory ductal origin. Genetic deletion of epithelial Sox10 leads to loss of secretory units, which reduces organ size and function, but the ductal tree is retained. [1] CA with myxoid stroma (nih. Louis Strong and diffuse staining of SOX10 (red chromogen) for adenoid cystic carcinoma in both epithelial and myoepithelial cells is observed in breast, salivary gland, and metastatic cases (A2, B2 Jan 13, 2022 · Biphasic, low grade malignancy of salivary gland Parotid is the most common location; rare in other salivary glands and minor salivary gland tissue Histologic features similar to basal cell adenoma but with evidence of invasive growth pattern Diagnosis based on demonstration of a dual cell population of centrally located ductal cells and abluminal basal cells with peripheral palisading of Apr 19, 2023 · Context. Read SOX10-positive salivary gland tumors: a growing list, including mammary analogue secretory carcinoma of the salivary gland, sialoblastoma, low-grade salivary duct carcinoma, basal cell adenoma/adenocarcinoma, and a subgroup of mucoepidermoid carcinoma In this study, we investigated potential fi fi markers for HCCC based on the characteristics of minor salivary gland acini, from which these tumors may originate. These neoplasms consist of heterogeneous groups of uncommon diseases that make diagnosis and treatment challenging for the clinical team. 6–13 Subsequently, it has been recognized that Sox10 is also ex- pressed in myoepithelial or basal cells, especially in the breast and salivary glands and in some tumors of these sites. Immunohistochemical stains for SOX10, Ki-67, c-KIT, β-catenin, epithelial membrane antigen (EMA), p63, cytokeratin 7 (CK7), cytokeratin 5/6 (CK5/6), and androgen receptor (AR) were performed. There is an equal sex distribution [5, 6, 17]. Paiva-Correia A, Hellquist H, Apolónio J, Castelo-Branco P. Basaloid squamous cell carcinoma (SCC) is a unique variant of SCC that shows Immunohistochemical stains for SOX10, Ki-67, c-KIT, β-catenin, epithelial membrane antigen (EMA), p63, cytokeratin 7 (CK7), cytokeratin 5/6 (CK5/6), and androgen receptor (AR) were performed. Oncocytic lesions of the salivary gland are classified as nodular oncocytic hyperplasia, oncocytoma, and oncocytic carcinoma in the fifth edition of the WHO Classification of Head and Neck Tumors. 54:Lymphatic endothelial cells - Lymph vessel development 78:NK-cells & T-cells - Immune system & Transcription 38:Proximal tubular cells - Transmembrane transport 70:Spermatocytes & Spermatids - Spermatid development Jun 27, 2024 · Background Intraductal carcinoma (IDC) of the salivary glands is a confounding entity, our understanding of which continues to evolve. Methods: To investigate this, we assessed the role of Sox10 in the submandibular gland (SMG) driven ductal cell line, SIMS, and primary cell culture monolayers of the SMG by overexpressing Sox10 using a doxycycline inducible Sox10 lentivirus. 05. SOX10 +ve - nuclear. Additionally, in the tissue microarray analysis, NKX3. Sox10-positive salivary gland tumors: a growing list, including Mammary analogue Secretory carcinoma of the salivary gland, Sialoblastoma, low-grade salivary duct carcinoma, basal cell adenoma/adenocarcinoma, and a subgroup of Mucoepidermoid carcinoma. Keywords: SOX10, secretory unit, cell fate, stem/progenitor cell, exocrine glands, salivary gland, mammary gland, lacrimal gland, KIT Graphical Abstract Open in a new tab Aug 1, 2013 · Moreover, the murine model suggested that SOX10 continued to be expressed from the developmental stage to adulthood in the acinar and both luminal and abluminal intercalated ducts in the major salivary gland. DOG1 is an established diagnostic marker for gastrointestinal stromal tumours (GIST), but has been reported in salivary gland tumours (SGT) as an acinar and intercalated duct marker. Material and Methods: 35 FNA CB of oncocytic salivary gland neoplasms, i. Therefore, Sox10 controls plasticity and multi-potency of epithelial KIT+cells in salivary glands and predicted to play a similar role in secretory organs, such as mammary, lacrimal, and salivary glands. doi: 10. Generally, the tumor cells are positive for p63 and p40 and negative for s100 and α-smooth muscle actin, suggesting that they differentiate into squamous Jun 17, 2017 · In the submandibular salivary gland (SMG), the most characterized of the three major salivary glands (considerably less is known about the development of the sublingual (SLG) and parotid (PG)), this begins with invagination of the epithelium into the condensing mesenchyme to form a single end bud containing SOX10-positive pre-acinar cells by Nov 19, 2024 · Purpose A major problem in establishing treatment strategies for salivary gland carcinomas is the difficulty of preoperative histologic subtyping. SOX10-positive salivary gland tumors: a growing list, including mammary analogue secretory carcinoma of the salivary gland, sialoblastoma, low-grade salivary duct carcinoma, basal cell adenoma/adenocarcinoma, and a subgroup of mucoepidermoid carcinoma. SRY-related HMG-box 10 (SOX10) protein is a transcription factor known to be cru … Dec 1, 2015 · Abstract. 0%, predominately expressed GATA3) and salivary gland tumors (69. Historically, the role of ancillary testing of salivary gland Summary Transcription factor SRY-related HMG-box 10 (SOX10) is an important marker for melanocytic, schwannian, myoepithelial, and some salivary gland tumors. Salivary gland stains: androgen receptor beta catenin calponin CK5/6 and CK5 CK7 DOG1 GATA3 GFAP HER2 HMGA2 IgG4 KIT LEF1 mammaglobin mucicarmine MYB NR4A3 (pending) p40 p63 pan-TRK PLAG1 S100 SMA SOX10 Superpages: entire chapter images virtual slides Index (Alphabetical table of contents) Apr 1, 2023 · In salivary glands, SOX10 is also expressed by acinar cells and in the intercalated ducts (including both luminal and abluminal cells). A total of 12 cases of br … SOX10-positive salivary gland tumors: a growing list, including mammary analogue secretory carcinoma of the salivary gland, sialoblastoma, low-grade salivary duct carcinoma, basal cell adenoma/adenocarcinoma, and a subgroup of mucoepidermoid carcinoma. It was previously considered as adenocarcinoma not otherwise specified (NOS). Last staff update: 11 January 2023 Page views in 2024: 6,169 Page views in 2025 to date: 12,193 Canalicular tumors of the salivary glands have recently emerged as an entity characterized by distinct morphology and recurrent HMGA2 gene rearrangement. At least four forms have been elucidated based on histomorphology, immunophenotype, and molecular profile: (1) intercalated duct-like, S100/SOX10+ with frequent NCOA4::RET fusions; (2) oncocytic, S100/SOX10+ with TRIM33::RET, NCOA4::RET, and BRAF V600E; (3 Jan 20, 2020 · Request PDF | An Accuracy Comparison of SOX10 with DOG1 Immunohistochemistry in Diagnosing Acinic Cell Carcinoma of Salivary Gland in Paraffin Tissue Samples | Background Morphological diversity Expression of SOX10 (DOM, SOX-10, WS2E, WS4) in salivary gland tissue. PMID Among carcinoma, SOX10 expression has been most frequently observed in salivary gland carcinoma and breast carcinoma, along with rare expression in head and neck squamous cell carcinoma, clear cell carcinoma, lung adenocarcinoma (LA), urothelial carcinoma, and colorectal carcinoma [14, 25]. All other benign and malignant salivary gland neoplasms were PLAG1-negative. 1016/j. On the basis of these findings, Sox10 has been explored as a marker for schwan- nian and melanocytic tumors of skin and soft tissue. Abstract Salivary gland tumors are relatively rare and morphologically diverse and heterogeneous tumors; therefore, histogenesis-based tumor markers are sorely needed to aid in diagnosing and determining the cell type of origin. Salivary gland neoplasms are rare, yet histologically diverse, posing a diagnostic challenge to many practicing pathologists. BACKGROUND: Recent findings in molecular pathology suggest that genetic translocation and/or overexpression of oncoproteins is important in salivary gland tumorigenesis and diagnosis. However, the existing protocols for inducing SG include limited factors, making it challenging to mimic the in vivo microenvironment of embryonic SGs. 14 – 16 Jun 17, 2016 · SOX10-positive salivary gland tumors: a growing List, including mammary analogue secretory carcinoma of the salivary gland, sialoblastoma, Low-grade salivary duct carcinoma, basal cell adenoma Oct 1, 2016 · Our data show SOX10 expression can be observed in salivary gland tumors with either one of the 4 cell types: acinic cells, cuboidal ductal cells with low-grade cytologic features, basaloid cells, and myoepithelial cells. In melanocytic cells the SOX10 gene expression is regulated by microphtalmia transcription factor. The SOX10 nuclear protein is widely expressed in glial cells, Schwann cells, and myoepithelial cells (salivary, bronchial, and mammary glands). lbcenr5 99 hc 8xwaoef zamjz2 m7rfg jbn4w rajju pthi ocm